Post-Doctoral Scientist Vaccine Immune Profiling
Company: Zoetis, Inc.
Posted on: January 15, 2020
POST-DOCTORAL SCIENTIST VACCINE IMMUNE PROFILING
Zoetis Veterinary Medicine Research and Development (VMRD),
Analytical Sciences Department in Kalamazoo, MI is seeking a
Post-Doctoral scientist to evaluate, optimize and adapt various
immune profiling platforms for companion animal and livestock
vaccines. The assay platforms will be correlated to host animal
cellular and humoral immunity.
Zoetis is the largest animal health company in the world with an
industry-leading research and development team. We are recruiting a
highly motivated Post-Doctoral scientist to evaluate and adapt
cell-based in vitro assays for use in viral or bacterial vaccine
immune response profiling and to assess their potential application
in vaccine development. This position will require an overall
understanding of methodologies used to assess vaccine induced
protective immune responses (both cellular and antibody). The
successful candidate will have working knowledge of antibody,
cytokine, cell proliferation or cytotoxicity-based immunoassays
using peripheral blood mononuclear cells (PMBCs) or other lymphoid
tissues from animals. The incumbent is expected to work in a
collaborative multidisciplinary team environment through
interacting with scientists from a variety of functional lines
within as well as with collaborators identified externally. In
addition, the incubent is expected to be familiar and use
conventional and new vaccine monitoring methodologies currently
available at Zoetis (e.g. flow cytometry, ELISA, ELISpot, cell
sorting, mutiplex cytokine assays) for evaluating humoral and
cellular immune responses. Fulfillment of job responsibilities
requires the candidate to leverage scientific and technical
advancements in areas of single cell technology, molecular biology,
and transgenic cell line generation and to think creatively to
standardize in vitro cell-based immunoassays to consistently
monitor vaccine quality.
Responsibilities include, but are not limited to the following:
* Review and assess scientific literature, external research
institutions/companies, and novel technology areas to develop
recommendations for applied immune assay development.
* Prepare and purify immune cells from na ve or vaccinated
* Design and conduct experiments to evaluate relevant antibody or
cellular immune responses for in vitro immune cell culture before
and after vaccine stimulation, with a focus on dose-dependent
response investigation and in vivo correlation.
* Improve assay consistency, accuracy, and precision with a goal of
standardizing assays for use in qualification of vaccines.
* Document, report, and communicate results in electronic
laboratory notebooks, technical reports, PowerPoint presentations,
and oral presentations.
* Interface with other scientists in a variety of functional lines
including Global Biological Research (GBR), Global Therapeutic
Research (GTR), and Analytical Sciences (AS).
* Manage collaborations with external partners on in vitro immune
model evaluation and conduct studies in Zoetis as needed to support
* Evaluate new technologies such as single immune cell isolation
and transgenic cell line generation to determine their
applicability for in vitro immunoassay development.
Expertise in animal immunobiology. Hands on experience in
preparation of PBMC and cells from lymphoid tissues. Familiarity
with cell sorting techniques is an advantage. Experience in
antibody, cytokine, and T cell assay techniques such as ELISA,
multiplex immunoassays, ELISpot, flow cytometric analysis of immune
cell surface markers, cell cytotoxicity,
opsonic/agglutination/adherence, and cell proliferation assays.
Track record of academic or industrial accomplishments in
immunological research and analytical immunoassay optimization.
Knowledge in molecular biology, single cell technology, and
transgenic cell line development. Proven ability to keep up with
scientific and technical advancement in biomedical research and to
evaluate new technologies.
* PhD in immunology, veterinary sciences or other closely related
disciplines with 0-3 years relevant research experience is
The ideal candidate would possess:
* Good oral and written communication skills
* Industrial or academic experience in a laboratory setting,
specifically in bacterial or viral immunoassays
* Ability to work efficiently in a group setting and to collaborate
with external partners.
Zoetis is committed to equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status or any other protected classification.
Disabled individuals are given an equal opportunity to use our
online application system. We offer reasonable accommodations as an
alternative if requested by an individual with a disability. Please
contact Zoetis Colleague Services at
email@example.com to request an accommodation.
Zoetis also complies with all applicable national, state and local
laws governing nondiscrimination in employment as well as
employment eligibility verification requirements of the Immigration
and Nationality Act. All applicants must possess or obtain
authorization to work in the US for Zoetis. Zoetis retains sole and
exclusive discretion to pursue sponsorship for the acquisition or
maintenance of nonimmigrant status and employment eligibility,
considering factors such as availability of qualified US workers.
Individuals requiring sponsorship must disclose this fact. Please
note that Zoetis seeks information related to job applications from
candidates for jobs in the U.S. solely via the following: (1) our
company website at www.Zoetis.com/careers site, or (2) via email
to/from addresses using only the Zoetis domain of @zoetis.com . In
addition, Zoetis does not use Google Hangout for any recruitment
related activities. Any solicitation or request for information
related to job applications with Zoetis via any other means and/or
utilizing email addresses with any other domain should be
disregarded. In addition, Zoetis will never ask candidates to make
any type of personal financial investment related to gaining
employment with Zoetis..
Keywords: Zoetis, Inc., Kalamazoo , Post-Doctoral Scientist Vaccine Immune Profiling, Other , Kalamazoo, Michigan
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