Associate Scientist / Senior Associate Scientist

Company: Zoetis
Location: Kalamazoo
Posted on: January 15, 2022

Job Description:

The Associate Scientist/Senior Associate Scientist in the Cell Line Development (CLD) Lab will play an essential role in the Zoetis Biopharmaceutical strategy for veterinary medicine. The successful applicant will contribute as an effective team member to drive the generation and characterization of stable cell lines in support of global development and the GMP (Good Manufacturing Practice) manufacture of veterinary biopharmaceuticals. The incumbent is expected to work hands-on at the bench while garnering strong technical skills and learning to provide technical leadership to project teams within their discipline. The Assoc. Scientist/Sr. Assoc. Scientist is expected to work with a degree of autonomy after training and contribute to the progress of projects in partnership with colleagues in Upstream and Downstream Process Development, Formulations, and Bioanalytical Sciences. To be successful, they will have knowledge of cell and molecular biology and experience with mammalian cell line tissue culture. Their work will involve the generation of stable Chinese Hamster Ovary (CHO) cells for expression of recombinant proteins and monoclonal antibodies. The position is based in Kalamazoo (Michigan, USA) with frequent interactions with colleagues and external partners located around the globe.

Responsibilities include:

-Application of cell and molecular biology knowledge and experience to generate and characterize stable CHO cell lines for the expression of recombinant proteins and monoclonal antibodies.

-Generate stable cell lines suitable for manufacture of both clinical supplies and commercial products in accord with GMP.

-Systematically optimize the genetic and cell culture parameters that impact the productivity of transfected cell lines.

-Contribute towards the optimization of CLD workflows that ensure clonality and stability of transfected cell lines.

-Author study reports that describe cell lineages and write sections of dossiers to support regulatory filings for new product registrations. This task will include the execution of protocols for testing the cell lines to ensure purity and identity in accord with global regulatory requirements.

-Represent the CLD function on technical teams for the development of new veterinary biopharmaceuticals.

-Strive for continuous improvement by streamlining existing workflows in order to increase the efficiency of CLD work.

-Assist in the implementation of strategies that support the mid-term goals of the CLD function. Such would include the evaluation of proprietary platform technologies offered for high-titer expression in CHO cell lines.

-Maintain electronic laboratory notebooks and records in accord with scientific protocol and applicable Standard Operating Procedures.

-Develop constructive working relationships in both internal and external networks for the purpose of strengthening the CLD function and to align team goals with organizational objectives.

-Demonstrate excellent organization skills in order to engage in multiple projects.

Preferred technical skills include:

-Knowledge in the scientific disciplines that support CLD, such as molecular biology, biochemistry, cell physiology, and microbiology.

-Hands-on practical experience with tools and approaches commonly used in CLD, which may include transfection, limiting dilution, FACS, imaging, etc.

-An ability to understand regulatory expectations for critical aspects of cell bank quality, including clonality and stability.

-Excellent written and verbal communication skills.

Education and experience include:

-BSc or MS in Biochemistry, Molecular Biology, Cell Biology or a related discipline with 0-3 years of industry or related experience in CLD.

Full time

Regular

Colleague

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of '@zoetis.com'. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.by Jobble

Keywords: Zoetis, Kalamazoo , Associate Scientist / Senior Associate Scientist, Other , Kalamazoo, Michigan