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Computational Toxicologist

Company: Zoetis, Inc
Location: Kalamazoo
Posted on: March 18, 2023

Job Description:

Role Description Zoetis Veterinary Medicine Research and Development (VMRD) is looking for a skilled Toxicologist to join the Toxicology group in Global Pharmacokinetics, Dynamics, Metabolism & Safety (GPDMS) based in Kalamazoo, MI, in a challenging and dynamic position that provides technical leadership and expertise in Computational and Genetic toxicology. The candidate will work across the VMRD organization to produce well-researched toxicological risk assessments that justify product safety across therapeutic areas and species, and to support Next Generation Risk Assessment (NGRA). The responsibilities include:

  • In silico and computational toxicology support: Develop and apply In Silico Toxicology (IST) tools such as QSAR and read-across approaches to predict physicochemical and toxicological endpoints and to aid decision-making, especially with regard to mutagenicity prediction
  • Conduct mutagenicity prediction for synthetic pathway assessment including the application of Threshold of Toxicological Concern (TTC)
  • Apply Integrated Approaches to Testing and Assessment (IATA) tools including New Approach Methodologies (NAM), Adverse outcome pathways (AOP), etc. to fill the gap between evolving scientific research and regulatory assessment challenges
  • Aid in the transition to NGRA: including developing new tools and protocols, documentation and integration of in silico toxicology data with non-animal methods, in vitro and in vivo toxicology data
  • Develop and apply state-of-the-art in silico assessments to aid toxicology representatives in the selection and optimization of large and small molecule therapeutics
  • Contribute to the analysis, integration, visualization, and interpretation of data to contextualize toxicological findings and generate predictive analyses
  • Provide scientific expertise in relevant chemistry, toxicology, and computational/ analytical areas
  • Preparation of scientific and technical documents such as safety expert reports, regulatory dossier, protocols, technical guidance, position paper, etc.There is an opportunity for this position to be remote.
    • Minimum skills
      • Ph.D. plus at least 5 years of experience in genetic toxicology, medicinal chemistry, computational toxicology, or related scientific discipline. A Master's degree in toxicology with 10 years of experience in the above-mentioned areas will be considered.
      • Demonstrated working knowledge of in silico toxicology, medicinal chemistry, genetic toxicology, and NAM fundamentals to evaluate structure-based models and interpret toxicological findings for internal and external regulatory decision making
      • Advanced skills in chemical risk assessment tools, toxicology databases, and literature searches
      • Excellence in technical writing and communication (regulatory communications, preparing protocols, reports, journal articles, dossiers, etc.)
      • Highly organized; Strong interpersonal skills with an ability to develop solid, long-term relationships, influence others, and adept at working across multiple cross-functional areas
        • Desirable skills, experience, and attributes:
          • Board certification in toxicology
          • Knowledge of global regulatory requirements for the preparation of chemical risk assessment
          • Experience in conducting studies in a regulated environment (GLP compliance).
          • Experience in evaluating the experimental design, and interpretation of studies assessing in vitro and in vivo toxicity and integration of in silico, in vitro, and in vivo dataFull timeRegularColleagueAny unsolicited resumes sent to Zoetis from a third party, such as an Agency recruiter, including unsolicited resumes sent to a Zoetis mailing address, fax machine or email address, directly to Zoetis employees, or to Zoetis resume database will be considered Zoetis property. Zoetis will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume.Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.

Keywords: Zoetis, Inc, Kalamazoo , Computational Toxicologist, Other , Kalamazoo, Michigan

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